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The medication drug called Sibutramine (trade name Meridia) is the newest weight-loss drug currently being prescribed and many others are in development or waiting for FDA approval.
The drugs worked by increasing Serotonin levels in the brain. Serotonin is a chemical (neurotransmitter) associated with improved mood, appetite and satiety. Fen-phen had a double action. It tricked the brain into believing the stomach was full, and increased a person's metabolic rate.
People did lose weight on these diet and weight-loss medications, but in 1997 after reports of heart valve disease, the makers of fenfluramine and dexfenfluramine withdrew these diet pills from the market. Prescriptions were no longer written for Redux, Pondimin or fen-phen.
During the 18 diet pills that fenfluramine (Pondimin) and dexfenfluramine (Redux) were being used as weight loss drugs, 14m prescriptions were written for people who wanted to lose weight..